Ammonium homeostasis

Across TCGA patient cohorts, RNA activity of the Ammonium homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHCG, RHCE, and ANKRD10, each associated with the pathway in up to 22 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ammonium homeostasis activity versus RHCG in ESCA (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	RHCG →	+6.504	+0.696	<.001	<.001	3	22
LAML	RHCE →	+1.944	+0.342	<.001	<.001	3	19
UVM	ANKRD10 →	-1.965	-0.118	<.001	<.001	2	18
UVM	ANKRD44 →	-1.086	-0.092	<.001	.002	2	17
SCLC	FGL2 →	-1.483	-0.206	.002	.001	2	16
UVM	GEM →	-1.854	-0.088	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097272 vs RHCG — ESCA

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