Ammonium homeostasis

Across TCGA patient cohorts, RNA activity of the Ammonium homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL4A1, MYLK, and CAVIN1_S118, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ammonium homeostasis activity versus COL4A1 in BRCA (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COL4A1 →	-0.457	-0.396	<.001	.002	3	5
BRCA	MYLK →	-0.345	-0.421	<.001	<.001	3	5
OV	CAVIN1_S118 →	-0.915	-0.926	.005	<.001	3	5
GBM	VCL →	-0.364	-0.676	.002	<.001	3	4
GBM	EEPD1_S173 →	+0.398	+0.620	.001	.001	3	4
BRCA	PARVA →	-0.418	-0.405	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097272 vs COL4A1 — BRCA

Explore this scatter interactively →