Ammonium homeostasis

Across TCGA cell cohorts, RNA activity of the Ammonium homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3C2B, DHRS2, and RPS17, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIK3C2B grouped by Ammonium homeostasis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PIK3C2B →	+1.824	+1.354	<.001	<.001	3	4
SKIN	DHRS2 →	-1.278	-0.850	.001	.004	3	4
BLOOD_Lymphoma	RPS17 →	+0.838	+1.636	.009	<.001	3	4
KIDNEY	TRIP11 →	-0.496	-1.193	.008	.006	3	4
UPPER_AERODIGESTIVE_TRACT	FCHO1 →	-1.482	-0.640	.002	.001	3	4
BLOOD_Myeloma	DHRS1 →	-0.943	-2.066	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIK3C2B by Ammonium homeostasis activity — BLOOD_Leukemia

Explore this box plot interactively →