Ammonium homeostasis

Across TCGA cell cohorts, RNA activity of the Ammonium homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLUL, TEDDM1, and LRRC28, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ammonium homeostasis activity versus GLUL in BLOOD_Lymphoma (Pearson r = 0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GLUL →	+5.340	+2.173	<.001	<.001	3	16
BLOOD_Lymphoma	TEDDM1 →	+0.029	+1.438	<.001	<.001	3	7
LUNG_NSCLC_LUAD	LRRC28 →	-0.755	-0.889	.001	<.001	2	7
SOFT_TISSUE	ARMC12 →	-0.484	-1.261	<.001	<.001	3	6
OVARY	STON2 →	+1.315	+0.952	.006	.003	3	5
OESOPHAGUS	ABLIM1 →	+1.453	+0.302	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097272 vs GLUL — BLOOD_Lymphoma

Explore this scatter interactively →