Omega-hydroxylase P450 pathway

Across TCGA patient cohorts, RNA activity of the Omega-hydroxylase P450 pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYP4F11, SVIL, and ADH5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Omega-hydroxylase P450 pathway activity versus CYP4F11 in LSCC (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CYP4F11 →	+1.533	+0.135	<.001	<.001	3	7
GBM	SVIL →	+0.697	+0.191	<.001	<.001	3	6
LUAD	ADH5 →	+0.281	+0.082	<.001	<.001	3	6
LSCC	CBR3 →	+0.677	+0.112	<.001	<.001	3	5
LSCC	CES1 →	+1.125	+0.098	<.001	<.001	3	5
LSCC	GSTM2 →	+0.716	+0.081	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097267 vs CYP4F11 — LSCC

Explore this scatter interactively →