Omega-hydroxylase P450 pathway

Across TCGA patient cohorts, RNA activity of the Omega-hydroxylase P450 pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCARA3, CYP4F11, and KIF16B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Omega-hydroxylase P450 pathway activity versus SCARA3 in LUAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SCARA3 →	+0.754	+0.599	.003	<.001	3	4
LSCC	CYP4F11 →	+3.372	+0.277	<.001	<.001	3	4
GBM	KIF16B →	+0.407	+0.133	.003	.002	3	4
LUAD	CLYBL →	+0.396	+0.696	.001	<.001	3	3
PDAC	PPIH →	-0.244	-0.596	.007	<.001	3	3
PDAC	VDAC2P5 →	-0.310	-0.536	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097267 vs SCARA3 — LUAD

Explore this scatter interactively →