Omega-hydroxylase P450 pathway

Across TCGA patient cohorts, RNA activity of the Omega-hydroxylase P450 pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYP4F11, TACC2, and TCF7L2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Omega-hydroxylase P450 pathway activity versus CYP4F11 in LSCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CYP4F11 →	+1.842	+0.299	<.001	<.001	3	4
PDAC	TACC2 →	-0.488	-0.986	<.001	<.001	3	2
GBM	TCF7L2 →	-0.794	-0.243	<.001	<.001	3	2
GBM	CYP1B1 →	+0.950	+0.195	<.001	<.001	3	2
GBM	KMO →	+1.229	+0.238	<.001	<.001	3	2
LSCC	MAP1B_S1016 →	+1.289	+0.301	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097267 vs CYP4F11 — LSCC

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