Self proteolysis

Across TCGA patient cohorts, RNA activity of the Self proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAB1, ALDOC, and LYVE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Self proteolysis activity versus STAB1 in GBM (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STAB1 →	+0.868	+0.125	.001	.003	3	4
HNSC	ALDOC →	-0.998	-0.173	.001	.001	3	4
HNSC	LYVE1 →	+0.728	+0.203	.001	<.001	3	4
HNSC	PCED1B →	+0.459	+0.201	.003	<.001	3	4
LSCC	SELL →	+1.263	+0.174	<.001	<.001	3	4
HNSC	SLC25A3P3 →	-0.961	-0.201	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097264 vs STAB1 — GBM

Explore this scatter interactively →