Self proteolysis

Across TCGA cell cohorts, RNA activity of the Self proteolysis pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMPRSS6, NLRP1, and IHH, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMPRSS6 grouped by Self proteolysis-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TMPRSS6 →	-0.477	-1.240	<.001	.008	3	11
OESOPHAGUS	NLRP1 →	-0.506	-2.030	.005	<.001	3	9
BLOOD_Lymphoma	IHH →	-0.447	-2.085	.006	<.001	3	8
CNS	RNF141 →	-0.311	-0.787	.003	.001	3	6
LIVER	CASP8 →	-0.443	-1.583	.001	.001	3	6
BLOOD_Myeloma	DHH →	-0.538	-2.190	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMPRSS6 by Self proteolysis activity — BONE

Explore this box plot interactively →