Self proteolysis

Across TCGA cell cohorts, RNA activity of the Self proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYB5RL, FLT3LG, and MYOT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYB5RL grouped by Self proteolysis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CYB5RL →	+0.606	+0.927	.002	.002	3	5
LUNG_NSCLC_LUAD	FLT3LG →	-0.744	-0.849	.004	.001	3	4
BONE	MYOT →	+0.240	+1.622	.007	<.001	3	4
BONE	TYRO3 →	-1.045	-1.846	.001	.001	3	4
PANCREAS	GNPDA1 →	+0.757	+1.347	.005	<.001	3	4
PANCREAS	CASP1 →	-2.330	-1.188	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYB5RL by Self proteolysis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →