Self proteolysis

Across TCGA cell cohorts, RNA activity of the Self proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFT74, TPRKB, and RPS18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Self proteolysis activity versus IFT74 in BLOOD_Myeloma (Pearson r = -0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	IFT74 →	-0.921	-0.269	.002	<.001	3	4
PANCREAS	TPRKB →	-0.763	-0.287	.001	<.001	3	4
PANCREAS	RPS18 →	-1.132	-0.362	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	MMP25 →	-0.693	-0.437	.002	<.001	3	3
OESOPHAGUS	STT3B →	-1.151	-0.377	.001	.002	3	3
OESOPHAGUS	PRDX3 →	-0.811	-0.599	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097264 vs IFT74 — BLOOD_Myeloma

Explore this scatter interactively →