Renal tubular secretion

Across TCGA cell cohorts, RNA activity of the Renal tubular secretion pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEMF, METTL17, and KDM1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEMF grouped by Renal tubular secretion-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NEMF →	-0.607	-0.938	<.001	.001	3	4
LARGE_INTESTINE	METTL17 →	-0.537	-1.571	.007	<.001	3	4
LIVER	KDM1A →	-0.616	-1.134	.008	.007	3	4
LIVER	EPB41L1 →	+1.996	+1.792	<.001	<.001	3	4
OVARY	STMN3 →	-2.346	-1.150	<.001	.001	3	4
PANCREAS	SNAPC1 →	-1.300	-1.389	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEMF by Renal tubular secretion activity — LARGE_INTESTINE

Explore this box plot interactively →