Mitochondrial respirasome assembly

Across TCGA patient cohorts, RNA activity of the Mitochondrial respirasome assembly pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX7A1, STMP1, and PSMA2, each associated with the pathway in up to 21 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial respirasome assembly activity versus COX7A1 in KICH (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	COX7A1 →	+3.109	+0.048	<.001	<.001	3	21
READ	STMP1 →	+0.650	+0.059	<.001	<.001	3	20
READ	PSMA2 →	+0.716	+0.054	<.001	<.001	3	17
TGCT	NDUFB2 →	+0.460	+0.041	<.001	<.001	3	17
UCEC	PFDN4 →	+0.839	+0.057	<.001	<.001	3	16
DLBC	ATP5F1E →	+0.656	+0.064	.001	<.001	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097250 vs COX7A1 — KICH

Explore this scatter interactively →