Mitochondrial respirasome assembly

Across TCGA patient cohorts, RNA activity of the Mitochondrial respirasome assembly pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMTC2, FCRL6, and PRICKLE2-AS3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial respirasome assembly activity versus TMTC2 in COAD (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMTC2 →	-0.388	-0.160	.001	.002	2	5
COAD	FCRL6 →	-0.476	-0.146	.006	.003	3	4
CCRCC	PRICKLE2-AS3 →	-0.390	-0.091	<.001	.004	3	4
LSCC	ICAM2 →	-0.415	-0.120	.001	.002	3	4
LSCC	FBXO27 →	+0.798	+0.106	.004	.003	3	4
BRCA	UQCRFS1P1 →	+1.743	+0.192	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097250 vs TMTC2 — COAD

Explore this scatter interactively →