Mitochondrial respirasome assembly

Across TCGA cell cohorts, RNA activity of the Mitochondrial respirasome assembly pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARID3B, AGTPBP1, and COMMD5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARID3B grouped by Mitochondrial respirasome assembly-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ARID3B →	-1.163	-2.395	.001	<.001	3	5
LUNG_NSCLC_LUSC	AGTPBP1 →	+0.993	+1.547	.002	.002	3	4
CNS	COMMD5 →	+0.918	+1.362	.001	.004	3	4
BLOOD_Leukemia	CD82 →	-3.813	-2.145	.004	.002	3	4
BREAST	P2RY2 →	-1.719	-0.928	<.001	.005	3	3
CNS	H2AZ2 →	+1.282	+1.324	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARID3B by Mitochondrial respirasome assembly activity — BONE

Explore this box plot interactively →