Hematopoietic stem cell migration to bone marrow

Across TCGA patient cohorts, RNA activity of the Hematopoietic stem cell migration to bone marrow pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAM2, COL6A1, and COL1A2, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic stem cell migration to bone marrow activity versus JAM2 in THYM (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	JAM2 →	+2.150	+0.080	<.001	<.001	3	28
UCS	COL6A1 →	+1.749	+0.130	<.001	<.001	3	27
UCS	COL1A2 →	+3.004	+0.139	<.001	<.001	3	27
TGCT	CD248 →	+1.758	+0.083	<.001	<.001	3	27
KIRC	TMEM255B →	+0.937	+0.086	<.001	<.001	3	27
UCS	COL15A1 →	+2.190	+0.116	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097241 vs JAM2 — THYM

Explore this scatter interactively →