Hematopoietic stem cell migration to bone marrow

Across TCGA patient cohorts, RNA activity of the Hematopoietic stem cell migration to bone marrow pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOX, SERPINE1, and TNFRSF10D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic stem cell migration to bone marrow activity versus LOX in UCEC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LOX →	+0.969	+0.622	.002	.004	3	5
BRCA	SERPINE1 →	+0.999	+0.667	.001	<.001	3	5
OV	TNFRSF10D →	+0.782	+0.596	.003	.009	3	5
LSCC	NUAK1 →	+0.734	+0.119	<.001	<.001	3	5
LUAD	SPACA6 →	+0.388	+0.520	.001	.001	3	4
CCRCC	TIMP3 →	+1.209	+0.354	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097241 vs LOX — UCEC

Explore this scatter interactively →