Hematopoietic stem cell migration to bone marrow

Across TCGA cell cohorts, RNA activity of the Hematopoietic stem cell migration to bone marrow pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXL6, LYN, and LPIN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXL6 grouped by Hematopoietic stem cell migration to bone marrow-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	FBXL6 →	-0.735	-0.839	<.001	.008	3	4
LUNG_NSCLC_LUAD	LYN →	-1.301	-0.821	.001	.004	3	4
BONE	LPIN1 →	-1.013	-1.252	.005	.007	3	4
SKIN	CCDC127 →	+0.692	+1.015	.003	.007	3	4
OVARY	WAPL →	-0.591	-1.069	.004	.006	3	4
BLOOD_Leukemia	PLAU →	-1.616	-1.036	.007	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXL6 by Hematopoietic stem cell migration to bone marrow activity — KIDNEY

Explore this box plot interactively →