Chromosome attachment to the nuclear envelope

Across TCGA patient cohorts, RNA activity of the Chromosome attachment to the nuclear envelope pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYDE1, PCOLCE, and DCN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chromosome attachment to the nuclear envelope activity versus SYDE1 in UCEC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYDE1 →	+0.559	+0.182	<.001	<.001	3	6
BRCA	PCOLCE →	+0.872	+0.249	.007	.002	3	6
GBM	DCN →	+1.130	+0.224	.004	.002	3	6
GBM	CCN1 →	+1.115	+0.234	<.001	<.001	3	6
LUAD	CAVIN1 →	+0.405	+0.169	<.001	<.001	3	6
CCRCC	GALNT15 →	+0.865	+0.213	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097240 vs SYDE1 — UCEC

Explore this scatter interactively →