Chromosome attachment to the nuclear envelope

Across TCGA cell cohorts, RNA activity of the Chromosome attachment to the nuclear envelope pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF570, MAD2L2, and RSU1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF570 grouped by Chromosome attachment to the nuclear envelope-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZNF570 →	+0.957	+1.277	.005	<.001	3	4
BONE	MAD2L2 →	+1.143	+1.509	.003	<.001	3	4
LUNG_SCLC	RSU1 →	+1.205	+1.224	.009	<.001	3	4
LUNG_NSCLC_LUSC	AEBP2 →	-0.901	-1.259	<.001	<.001	3	4
LUNG_NSCLC_LUSC	PKP2 →	-1.878	-1.429	.004	<.001	3	4
KIDNEY	ZDHHC12 →	+1.098	+1.548	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF570 by Chromosome attachment to the nuclear envelope activity — PANCREAS

Explore this box plot interactively →