Chromosome attachment to the nuclear envelope

Across TCGA cell cohorts, RNA activity of the Chromosome attachment to the nuclear envelope pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUZ12, TNFAIP3, and ITPKA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chromosome attachment to the nuclear envelope activity versus SUZ12 in LARGE_INTESTINE (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SUZ12 →	-0.814	-0.102	.005	.009	2	5
BLOOD_Lymphoma	TNFAIP3 →	+2.493	+1.225	<.001	<.001	3	4
BLOOD_Lymphoma	ITPKA →	+1.632	+1.463	<.001	<.001	3	4
BLOOD_Lymphoma	DCK →	-1.862	-1.899	<.001	<.001	3	4
BLOOD_Lymphoma	MRPL16 →	-0.860	-1.313	<.001	<.001	3	4
BLOOD_Lymphoma	PCCA →	+2.565	+1.431	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097240 vs SUZ12 — LARGE_INTESTINE

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