Cellular response to toxic substance

Across TCGA patient cohorts, RNA activity of the Cellular response to toxic substance pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNTB2_S222, TLN1_S2040, and TNS2_S120, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to toxic substance activity versus SNTB2_S222 in GBM (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNTB2_S222 →	+0.913	+0.048	<.001	<.001	3	9
LSCC	TLN1_S2040 →	+0.575	+0.033	<.001	<.001	3	9
BRCA	TNS2_S120 →	+0.580	+0.028	<.001	.001	3	9
COAD	TOP1 →	-0.466	-0.025	<.001	<.001	3	9
GBM	PLA2G2A →	+1.505	+0.047	<.001	<.001	3	9
UCEC	SNTB2_S95 →	+0.559	+0.076	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097237 vs SNTB2_S222 — GBM

Explore this scatter interactively →