Cellular response to toxic substance

Across TCGA cell cohorts, RNA activity of the Cellular response to toxic substance pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMCES, QSOX1, and ZFP82, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HMCES grouped by Cellular response to toxic substance-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HMCES →	+0.774	+0.826	<.001	.001	3	3
BLOOD_Leukemia	QSOX1 →	-1.735	-0.863	.009	.008	3	3
BLOOD_Leukemia	ZFP82 →	+1.208	+0.665	.004	.002	3	3
KIDNEY	ABL2 →	+1.058	+1.059	<.001	.003	3	3
PANCREAS	SCNM1 →	+0.526	+0.825	.007	.004	3	3
BLOOD_Myeloma	HMGXB4 →	+0.588	+1.390	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HMCES by Cellular response to toxic substance activity — LARGE_INTESTINE

Explore this box plot interactively →