Cellular response to toxic substance

Across TCGA cell cohorts, RNA activity of the Cellular response to toxic substance pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTK1, WNT10A, and AKR1C1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to toxic substance activity versus GSTK1 in STOMACH (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GSTK1 →	+1.191	+0.362	.005	<.001	3	6
LARGE_INTESTINE	WNT10A →	-1.840	-0.257	.008	.003	3	6
LUNG_NSCLC_LUSC	AKR1C1 →	+7.334	+0.311	<.001	<.001	3	5
OESOPHAGUS	PTHLH →	-3.668	-0.296	.008	.002	3	5
OESOPHAGUS	SLC43A1 →	+1.419	+0.200	.009	.003	3	5
STOMACH	LTBP2 →	-1.905	-0.330	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097237 vs GSTK1 — STOMACH

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