Cellular response to toxic substance

Across TCGA cell cohorts, RNA activity of the Cellular response to toxic substance pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CBR3, NANS, and GSS, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to toxic substance activity versus CBR3 in LUNG_NSCLC_LUSC (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CBR3 →	+3.168	+0.322	.002	.003	3	16
STOMACH	NANS →	+2.252	+0.324	<.001	<.001	3	15
URINARY_TRACT	GSS →	+2.456	+0.304	.002	.002	3	15
URINARY_TRACT	TKT →	+4.087	+0.409	.001	.002	3	15
LUNG_NSCLC_LUSC	TALDO1 →	+3.990	+0.375	<.001	<.001	3	15
STOMACH	GSR →	+2.574	+0.367	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097237 vs CBR3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →