Lysosomal membrane organization

Across TCGA patient cohorts, RNA activity of the Lysosomal membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAML2, PARD3B, and UTRN, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lysosomal membrane organization activity versus MAML2 in THYM (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	MAML2 →	+1.101	+0.086	<.001	<.001	3	30
THYM	PARD3B →	+1.265	+0.099	<.001	<.001	3	29
THYM	UTRN →	+1.321	+0.084	<.001	<.001	3	29
CHOL	CALCRL →	+1.564	+0.080	<.001	<.001	3	29
THYM	PEAK1 →	+1.074	+0.096	<.001	<.001	3	29
KICH	MCPH1 →	+0.738	+0.048	.004	.005	1	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097212 vs MAML2 — THYM

Explore this scatter interactively →