Lysosomal membrane organization

Across TCGA patient cohorts, RNA activity of the Lysosomal membrane organization pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCDC130, NUP54, and PIGR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lysosomal membrane organization activity versus CCDC130 in PDAC (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CCDC130 →	-0.521	-0.076	<.001	.003	3	5
CCRCC	NUP54 →	-0.076	-0.032	.009	.007	3	4
GBM	PIGR →	+0.564	+0.049	.001	.001	3	4
LSCC	SRCIN1_S434 →	+1.201	+0.050	.001	.001	3	4
OV	TPRKB →	-0.332	-0.054	.002	.001	3	4
LUAD	INPP4B →	+0.632	+0.041	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097212 vs CCDC130 — PDAC

Explore this scatter interactively →