Lysosomal membrane organization

Across TCGA patient cohorts, RNA activity of the Lysosomal membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C5, SLC46A2, and LINC01354, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lysosomal membrane organization activity versus C5 in LUAD (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	C5 →	-0.976	-0.134	.002	.004	3	3
LUAD	SLC46A2 →	-0.864	-0.158	<.001	<.001	3	3
LUAD	LINC01354 →	-0.319	-0.162	.004	.007	3	3
COAD	MIR4786 →	-0.730	-0.144	.001	.001	2	4
COAD	TLR2 →	-0.875	-0.196	.001	<.001	3	3
COAD	CCIN →	-0.165	-0.126	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097212 vs C5 — LUAD

Explore this scatter interactively →