Lysosomal membrane organization

Across TCGA cell cohorts, RNA activity of the Lysosomal membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM120AOS, HES6, and SNX29, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lysosomal membrane organization activity versus FAM120AOS in PANCREAS (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FAM120AOS →	+0.700	+1.147	.004	.005	3	6
SKIN	HES6 →	+2.427	+1.274	.004	<.001	3	6
BLOOD_Leukemia	SNX29 →	+0.729	+1.136	<.001	<.001	3	5
LIVER	POM121 →	+1.135	+1.799	.006	<.001	3	5
CNS	FDX1 →	+0.721	+1.067	.001	.007	3	5
SKIN	ATG4D →	+0.883	+0.861	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097212 vs FAM120AOS — PANCREAS

Explore this scatter interactively →