Cellular response to gonadotropin-releasing hormone

Across TCGA patient cohorts, RNA activity of the Cellular response to gonadotropin-releasing hormone pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STX11, DAPK1, and APOL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to gonadotropin-releasing hormone activity versus STX11 in LSCC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STX11 →	-0.358	-0.586	.003	.002	3	5
UCEC	DAPK1 →	-0.270	-0.472	.004	.007	3	4
UCEC	APOL2 →	-0.417	-0.584	.004	<.001	3	4
OV	YLPM1 →	+0.279	+0.089	<.001	<.001	3	4
OV	GBP2 →	-0.587	-0.073	<.001	.001	3	4
LSCC	ATRX_S92 →	+0.490	+0.897	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097211 vs STX11 — LSCC

Explore this scatter interactively →