Response to gonadotropin-releasing hormone

Across TCGA patient cohorts, RNA activity of the Response to gonadotropin-releasing hormone pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPATS2L, TDRD7, and AGPAT5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to gonadotropin-releasing hormone activity versus SPATS2L in UCEC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPATS2L →	-0.338	-0.091	<.001	<.001	3	4
OV	TDRD7 →	-0.364	-0.070	.003	.006	2	5
LUAD	AGPAT5 →	+0.370	+0.068	.001	<.001	3	4
UCEC	KCTD9 →	-0.185	-0.075	.003	<.001	3	4
GBM	APEX1 →	+0.328	+0.074	<.001	<.001	3	4
LSCC	NMI →	-0.284	-0.058	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097210 vs SPATS2L — UCEC

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