Response to gonadotropin-releasing hormone

Across TCGA patient cohorts, RNA activity of the Response to gonadotropin-releasing hormone pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPNE1, ECT2, and MIR5700, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to gonadotropin-releasing hormone activity versus CPNE1 in GBM (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CPNE1 →	+0.285	+0.397	.003	.005	3	4
OV	ECT2 →	-0.567	-0.170	.002	.008	3	3
CCRCC	MIR5700 →	+0.708	+0.571	<.001	.007	3	3
UCEC	MIR99AHG →	+0.959	+0.447	<.001	.002	3	3
GBM	BAP1 →	+0.206	+0.467	.006	.006	3	3
OV	MMADHCP2 →	-0.716	-0.190	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097210 vs CPNE1 — GBM

Explore this scatter interactively →