Response to gonadotropin-releasing hormone

Across TCGA cell cohorts, RNA activity of the Response to gonadotropin-releasing hormone pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF8, KCNIP2, and TOB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLF8 grouped by Response to gonadotropin-releasing hormone-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KLF8 →	-0.947	-1.513	.005	<.001	3	5
SOFT_TISSUE	KCNIP2 →	+0.459	+0.884	.003	.008	3	4
SOFT_TISSUE	TOB2 →	+0.786	+0.925	<.001	.005	3	4
BONE	IDH3B →	+0.718	+1.548	.008	.004	2	5
BONE	SART3 →	+0.969	+1.198	<.001	.006	3	4
URINARY_TRACT	MRPS18A →	+0.366	+1.461	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLF8 by Response to gonadotropin-releasing hormone activity — OESOPHAGUS

Explore this box plot interactively →