Response to gonadotropin-releasing hormone

Across TCGA cell cohorts, RNA activity of the Response to gonadotropin-releasing hormone pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF621, UPK3B, and ZNF267, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF621 grouped by Response to gonadotropin-releasing hormone-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZNF621 →	-0.206	-0.308	.006	.005	3	4
LIVER	UPK3B →	-0.212	-0.285	.001	.001	3	4
STOMACH	ZNF267 →	-0.193	-0.264	<.001	.004	3	4
STOMACH	XYLB →	+0.157	+0.361	<.001	.003	3	4
SOFT_TISSUE	SYVN1 →	+0.176	+0.285	.005	.007	3	3
BLOOD_Myeloma	ARPC3 →	-0.245	-0.324	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF621 by Response to gonadotropin-releasing hormone activity — BLOOD_Myeloma

Explore this box plot interactively →