Renal filtration

Across TCGA patient cohorts, RNA activity of the Renal filtration pathway is significantly associated with the RNA expression of multiple genes, with the BLCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFRB, CD93, and CALCRL, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal filtration activity versus PDGFRB in BLCA (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PDGFRB →	+1.888	+0.089	<.001	<.001	3	33
UCS	CD93 →	+1.877	+0.092	<.001	<.001	3	33
CHOL	CALCRL →	+1.485	+0.106	<.001	<.001	3	33
UCS	MYLK →	+2.030	+0.092	<.001	<.001	2	34
CHOL	IGHV3-11 →	+3.213	+0.099	<.001	<.001	3	32
CHOL	COL15A1 →	+2.642	+0.141	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097205 vs PDGFRB — BLCA

Explore this scatter interactively →