Renal filtration

Across TCGA patient cohorts, RNA activity of the Renal filtration pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAB1, KANK2_S540, and LMOD1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal filtration activity versus STAB1 in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STAB1 →	+0.700	+0.112	<.001	<.001	3	10
LSCC	KANK2_S540 →	+0.727	+0.074	<.001	.001	3	10
UCEC	LMOD1 →	+1.253	+0.080	<.001	<.001	3	10
UCEC	MYLK →	+0.929	+0.086	<.001	<.001	3	10
UCEC	PPM1F →	+0.394	+0.095	<.001	<.001	3	10
UCEC	ARHGEF17 →	+0.414	+0.095	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097205 vs STAB1 — GBM

Explore this scatter interactively →