Execution phase of apoptosis

Across TCGA patient cohorts, RNA activity of the Execution phase of apoptosis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THBS3, RCN3, and SEPTIN4_S432, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Execution phase of apoptosis activity versus THBS3 in BRCA (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	THBS3 →	+0.589	+0.022	<.001	<.001	3	4
GBM	RCN3 →	+0.581	+0.038	<.001	<.001	3	4
CCRCC	SEPTIN4_S432 →	+0.520	+0.035	<.001	<.001	3	4
HNSC	SLC3A2 →	-0.706	-0.046	<.001	<.001	3	4
PDAC	STXBP1 →	+0.264	+0.024	.002	.001	3	4
BRCA	TLN1_S2040 →	+0.821	+0.020	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097194 vs THBS3 — BRCA

Explore this scatter interactively →