Execution phase of apoptosis

Across TCGA patient cohorts, RNA activity of the Execution phase of apoptosis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRG3, ZC3H14, and BTBD7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Execution phase of apoptosis activity versus ADGRG3 in PDAC (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ADGRG3 →	-1.082	-0.203	<.001	<.001	3	5
LUAD	ZC3H14 →	+0.444	+0.178	<.001	<.001	3	4
LUAD	BTBD7 →	+0.286	+0.084	<.001	.009	3	4
GBM	COQ6 →	+0.322	+0.159	<.001	.001	3	4
OV	MRPL50 →	+0.446	+0.154	.001	.001	3	4
OV	RBMX →	+0.446	+0.154	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097194 vs ADGRG3 — PDAC

Explore this scatter interactively →