Execution phase of apoptosis

Across TCGA cell cohorts, RNA activity of the Execution phase of apoptosis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB42, RPL6, and HELZ2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Execution phase of apoptosis activity versus ZBTB42 in BLOOD_Leukemia (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZBTB42 →	+0.484	+0.117	.001	.001	3	5
BLOOD_Lymphoma	RPL6 →	-0.403	-0.206	.003	<.001	3	4
LUNG_NSCLC_LUAD	HELZ2 →	+0.745	+0.160	.002	.005	3	4
LUNG_NSCLC_LUAD	DAB2 →	-1.702	-0.209	<.001	<.001	3	4
LIVER	IFNGR1 →	-1.626	-0.341	.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	WBP2 →	+0.878	+0.216	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097194 vs ZBTB42 — BLOOD_Leukemia

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