Extrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Extrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GUCY2D, OSBPL10, and B3GALNT2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extrinsic apoptotic signaling pathway activity versus GUCY2D in COAD (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GUCY2D →	+0.114	+0.321	.002	.005	3	1
COAD	OSBPL10 →	-0.344	-0.297	.007	<.001	3	1
COAD	B3GALNT2 →	-0.684	-0.335	.005	.007	3	1
COAD	IL24 →	-2.152	-0.382	.003	<.001	3	1
COAD	ZNF701 →	-0.688	-0.297	.004	<.001	3	1
COAD	CCR9 →	-0.289	-0.294	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097191 vs GUCY2D — COAD

Explore this scatter interactively →