Extrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Extrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE4C, SPA17, and PYURF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extrinsic apoptotic signaling pathway activity versus PDE4C in BREAST (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PDE4C →	-0.243	-0.617	.007	.001	3	4
BLOOD_Lymphoma	SPA17 →	-0.782	-0.820	<.001	<.001	3	3
SKIN	PYURF →	-0.496	-0.496	.004	.007	3	3
OESOPHAGUS	ADAL →	+0.705	+0.450	.009	.009	3	3
LUNG_NSCLC_LUAD	SLC25A27 →	-0.739	-0.387	.007	.003	3	3
CNS	ACYP2 →	-0.916	-0.869	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097191 vs PDE4C — BREAST

Explore this scatter interactively →