Dentinogenesis

Across TCGA patient cohorts, RNA activity of the Dentinogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL6A2, FAM20C, and SERPINE1, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dentinogenesis activity versus COL6A2 in BLCA (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	COL6A2 →	+1.701	+0.119	<.001	<.001	3	30
BLCA	FAM20C →	+1.787	+0.147	<.001	<.001	3	30
SARC	SERPINE1 →	+2.549	+0.138	<.001	<.001	3	29
SARC	MMP19 →	+1.462	+0.094	<.001	<.001	3	29
TGCT	COL6A1 →	+1.787	+0.112	<.001	<.001	3	29
BLCA	ITGA5 →	+1.430	+0.115	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097187 vs COL6A2 — BLCA

Explore this scatter interactively →