Dentinogenesis

pathway activity — cross-omics
GO:0097187Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Dentinogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMC2, ADM, and AJUBA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCLAMC2 →+1.514+0.709<.001.00134
BRCAADM →+0.862+0.336<.001.00834
UCECAJUBA →-0.570-0.582<.001.00133
COADACVRL1 →+0.463+0.353.001.00533
COADOR10D1P →+0.111+0.473<.001<.00133
LUADLINC00871 →+0.370+0.420<.001.00933
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration