Amelogenesis

Across TCGA patient cohorts, RNA activity of the Amelogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGAM, MNDA, and DOK3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amelogenesis activity versus ITGAM in GBM (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ITGAM →	+1.002	+0.123	<.001	<.001	3	9
GBM	MNDA →	+1.162	+0.096	<.001	<.001	3	9
GBM	DOK3 →	+0.697	+0.092	<.001	<.001	3	8
LSCC	MNDA_S227 →	+1.219	+0.072	<.001	<.001	3	7
GBM	SKAP2 →	+0.727	+0.102	<.001	<.001	3	7
GBM	HK3 →	+0.830	+0.056	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097186 vs ITGAM — GBM

Explore this scatter interactively →