Amelogenesis

Across TCGA patient cohorts, RNA activity of the Amelogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IKZF3, SYNE3, and CCDC80, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amelogenesis activity versus IKZF3 in HNSC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IKZF3 →	-0.927	-0.655	.001	.001	3	4
HNSC	SYNE3 →	-0.457	-0.495	.001	<.001	3	4
PDAC	CCDC80 →	-0.536	-0.786	.005	<.001	3	4
LSCC	CSTF3-DT →	-0.112	-0.460	.003	.001	3	4
LSCC	TNS4 →	+0.823	+0.400	.003	<.001	3	4
LSCC	CLCA2 →	+2.624	+0.631	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097186 vs IKZF3 — HNSC

Explore this scatter interactively →