Amelogenesis

Across TCGA cell cohorts, RNA activity of the Amelogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STX1A, LRRC14, and TIGAR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STX1A grouped by Amelogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	STX1A →	-2.010	-1.747	<.001	<.001	3	6
LUNG_NSCLC_LUSC	LRRC14 →	+0.646	+1.398	.007	.001	3	5
BLOOD_Leukemia	TIGAR →	+1.095	+0.486	.002	.006	3	4
LIVER	TMEM141 →	+1.799	+1.678	.001	.004	3	4
OESOPHAGUS	SLC5A6 →	+1.177	+1.560	<.001	<.001	3	4
OESOPHAGUS	FAM117B →	+0.687	+1.238	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STX1A by Amelogenesis activity — LIVER

Explore this box plot interactively →