Amelogenesis

Across TCGA cell cohorts, RNA activity of the Amelogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAX, TRRAP, and CPT1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAX grouped by Amelogenesis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAX →	-0.535	-0.260	<.001	.001	3	6
LUNG_NSCLC_LUSC	TRRAP →	-0.446	-0.252	.004	.004	3	5
BREAST	CPT1B →	+0.149	+0.176	.002	.001	3	5
LUNG_NSCLC_LUSC	SCGB1D1 →	+0.280	+0.259	.005	.004	3	4
LUNG_NSCLC_LUSC	ADAM29 →	+0.151	+0.256	.006	.001	2	5
OVARY	DYRK1A →	-0.242	-0.208	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAX by Amelogenesis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →