Amelogenesis

Across TCGA cell cohorts, RNA activity of the Amelogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VASH1, MAP3K5, and YBX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amelogenesis activity versus VASH1 in SOFT_TISSUE (Pearson r = -0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	VASH1 →	-2.222	-1.732	.004	<.001	3	4
BREAST	MAP3K5 →	+1.492	+1.424	<.001	<.001	3	4
OESOPHAGUS	YBX1 →	-0.557	-1.247	<.001	<.001	3	4
BLOOD_Lymphoma	PHGDH →	-5.804	-1.585	.003	.001	3	3
LUNG_NSCLC_LUSC	NFKBIZ →	+2.476	+2.179	.008	<.001	3	3
LUNG_NSCLC_LUSC	PPP1R15B →	-1.059	-2.180	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097186 vs VASH1 — SOFT_TISSUE

Explore this scatter interactively →