Ruffle assembly

Across TCGA patient cohorts, RNA activity of the Ruffle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCL_S67, SRPK1_S311, and CCNL1_S374, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ruffle assembly activity versus NCL_S67 in PDAC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NCL_S67 →	-0.652	-0.031	.005	.006	3	7
BRCA	SRPK1_S311 →	-0.625	-0.028	<.001	<.001	3	7
GBM	CCNL1_S374 →	-0.470	-0.050	<.001	.003	3	7
LSCC	ZC3H13_T1033 →	-0.277	-0.034	.002	.003	3	6
LUAD	DDX21_S89 →	-0.734	-0.035	.007	.005	3	6
GBM	SNRPB2 →	-0.220	-0.054	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097178 vs NCL_S67 — PDAC

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