Ruffle assembly

Across TCGA patient cohorts, RNA activity of the Ruffle assembly pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXO1, FAM83D, and CENPF, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ruffle assembly activity versus EXO1 in LSCC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EXO1 →	-0.538	-0.198	<.001	.004	3	6
HNSC	FAM83D →	-0.954	-0.208	<.001	.002	3	5
HNSC	CENPF →	-0.955	-0.163	.001	<.001	3	5
BRCA	KIF18A →	-0.830	-0.233	<.001	.006	3	5
GBM	CCNB2 →	-0.829	-0.168	<.001	.006	3	5
GBM	KIF4A →	-0.935	-0.198	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097178 vs EXO1 — LSCC

Explore this scatter interactively →